Biomaterial-Mediated Control of Immunity for Regenerative Medicine

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Biomaterials for Immunity and Cancer
Room: 210/211


Previous strategies to control biomaterial-immune cell interactions involved inhibition of or hiding from immunity. With increasing understanding of the importance of the immune system in mediating tissue repair, next-generation strategies are designed to actively stimulate specific immune cells or promote specific processes in the immune system in order to enhance tissue regeneration. This session will focus on biomaterial design and/or drug delivery strategies to actively control immunity for regenerative medicine applications. Cell targets include neutrophils, monocytes, macrophages, dendritic cells, T cells, and B cells. Biomaterial strategies include drug/cytokine delivery, structural biomimicry, nanomaterials, and tissue engineering strategies.


  • 1:45 p.m. 394. Localizing pro-regenerative inflammation via nanoscale fiber scaffolds improves volumetric muscle defect healing, E Botchwey*, C San Emeterio, M Ogle; Georgia Institute of Technology, Atlanta, GA

  • 2:00 p.m. 395. Sequential Cytokine Delivery for Modification of the Host Immune Response to Implants in the Context of Aging, D Hachim, B Brown*; University of Pittsburgh, Pittsburgh, PA

  • 2:15 p.m. 396. Modulation of Leukocyte Infiltration into Biomaterial Scaffolds Engineered to Release Anti-Inflammatory Small Molecules, K Murphy, M Gower*; University of South Carolina, Columbia, SC

  • 2:30 p.m. 397. Novel Microparticle-based Strategy to Maintain Macrophage Phenotype at Sites of Injury, K Wofford*(1), B Singh(1), K Cullen(2), K Spiller(1); (1)Drexel University, Philadelphia, PA, (2)University of Pennsylvania, Philadelphia, PA

  • 2:45 p.m. 398. A novel “anti-vaccine” for the treatment of collagen-induced arthritis, R Allen*, S Chizari, J Lewis; UC Davis, Davis, CA

  • 3:00 p.m. 399. Allogeneic Ovarian Tissue Encapsulated in Poly(Ethylene Glycol)-Vinyl Sulfone and TheraCyte Immunoisolates and Restores Endocrine Function in Adult Ovariectomized Mice, A David*, J Day, A Lefferts, M Cascalho, A Shikanov; University of Michigan, Ann Arbor, MI

  • 3:15 p.m. 400. Anti-inflammatory Nanomolecules to Modulate Inflammation in a Mouse Model of Crohn's Disease, M. Karver(1), A. Sharma(2), N. Fuller(2), M. Bury*(2); (1)Northwestern University, Chicago, IL, (2)Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, IL

  • 3:30 p.m. 401. Understanding the role of macrophages in the FBR-mediated reduction of in vitro osteogenic capabilities of MC3T3-E1 cells encapsulated in a biomimetic poly(ethylene glycol) hydrogel, L. Saleh*, M. Carles-Carner, A. Frederickson, C. Vanderheyden, S. Bryant; University of Colorado, Boulder, CO