Engineered Microenvironments to Model Cancer

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Wound Healing and Cellular Microenvironment
Room: Grand Ballroom D


Biomaterials have been invaluable tools for understanding how cells respond to their microenvironment in both health and disease. Here, we invite contributions that develop biomaterial platforms for cell culture or tissue engineering. Session topics include the following: understanding of the mechanisms that determine cellular responses to disease/injury, determining how biophysical and biochemical cues alter cellular behavior in 3D, identifying differences between 2D and 3D microenvironments in mediating cellular phenotype or response to treatment, developing complex tissue microstructures/organioids, culturing multiple types of cells within complex microenvironments, driving or enriching specific populations, developing improved approaches for utilization of patient derived or difficult to culture cells, drug screening within engineered microenvironments, and engineering microenvironments for therapeutic purposes.


  • 10:15 a.m. 456. Tunable Biomaterials to Identify Mechanisms of ECM-Mediated Drug Resistance in Breast Cancer, A Schwartz*(1), L Barney(1), L Jansen(1), T Nguyen(1), C Hall(1), A Meyer(2), S Peyton(1); (1)University of Massachusetts Amherst, Amherst, MA, (2)Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA

  • 10:30 a.m. 457. 3D in vitro Recapitulation of the Native Breast Tumor Microenvironment in a Vascularized Tumor Mimetic Microfluidic Chip, B Anbiah*(1), I Hassani(1), N Habbit(1), S Jasper(1), M Egghert(1), B Prabhakarpandian(2), R Arnold(1), E Lipke(1); (1)Auburn University, Auburn, AL, (2)Biomedical technology, CFD Research Corporation, Huntsville, AL

  • 10:45 a.m. 458. Desmoplasia-mimetic gels with modular and temporal properties for modeling pancreatic cancer progression, H. Liu*(1), C. Lin(2); (1)Purdue University, West Lafayette, IN, (2)IUPUI, Indianapolis, IN

  • 11:00 a.m. 459. Mineralized matrices to model malignant microcalcification-induced breast tumor progression, M Singh, A Patel, S Rangnathan, S Sant*; University of Pittsburgh, Pittsburgh, PA

  • 11:15 a.m. 460. Designer tumor microenvironments to study B cell lymphoid tumors and MALT1 signaling, S. Shah*(1), E. Abeles(1), K. Lee(1), L. Fontan(2), A. Melnick(2), A. Singh(1); (1)Cornell University, Ithaca, NY, (2)Weill Cornell Medical College, New York, NY

  • 11:30 a.m. 461. Perivascular Signals Alter Global Genomic Profile of Glioblastoma and Response to Temozolomide in an Engineered Tumor Microenvironment, M. Ngo*, B. Harley; University of Illinois Urbana-Champaign, Urbana, IL

  • 11:45 a.m. 462. Glioblastoma stem cell phenotype regulation via CD44 on tumor microenvironment mimicking hyaluronic acid hydrogel, S. Park*, A. Narkhede, S. Rao, Y. Kim; The University of Alabama, Tuscaloosa, AL

  • 12:00 noon 463. Development of a 3D Scaffold for Modelling Aggressive Lymphoma, L. Bahlmann*(1), A. Baker(1), R. Laister(2), M. Shoichet(1); (1)University of Toronto, Toronto, ON, (2)Cancer Institute, Princess Margaret Hospital, Toronto, ON