Engineered Microenvironments in to Model Disease

Timeslot: Wednesday, April 11, 2018 - 1:00pm to 3:00pm
Track: Wound Healing and Cellular Microenvironment
Room: 208/209


Biomaterials have been invaluable tools for understanding how cells respond to their microenvironment in both health and disease. Here, we invite contributions that develop biomaterial platforms for cell culture or tissue engineering. Session topics include the following: understanding of the mechanisms that determine cellular responses to disease/injury, determining how biophysical and biochemical cues alter cellular behavior in 3D, identifying differences between 2D and 3D microenvironments in mediating cellular phenotype or response to treatment, developing complex tissue microstructures/organioids, culturing multiple types of cells within complex microenvironments, driving or enriching specific populations, developing improved approaches for utilization of patient derived or difficult to culture cells, drug screening within engineered microenvironments, and engineering microenvironments for therapeutic purposes.


  • 1:00 p.m. 32. Recapitulating the 3D Microenvironment of the Human Neural Microinterface with the Blood Brain Barrier, S Ahn*, J Yom, C Hovell, Y Sei, Y Kim; Georgia Institute of Technology, Atlanta, GA

  • 1:15 p.m. 33. Electrospun fibrillar biomaterial platforms with tunable mechanics as fibrosis disease models, M. Davidson*, K. Song, M. Lee, J. Llewellyn, R. Wells, J. Burdick; University of Pennsylvania, Philadelphia, PA

  • 1:30 p.m. 34. Matrix Elasticity Defines Cell Migration Modes in Aligned Fibrous Microenvironments, W. Wang*, C. Davidson, B. Baker; University of Michigan, Ann Arbor, MI

  • 1:45 p.m. 35. Non-Invasive Oxygen Monitoring Using Fluorescent Hydrogel Microparticles, R. Wilson*, K. Grande-Allen; Rice University, Houston, TX

  • 2:00 p.m. 36. On Chip Reconstitution of Atherogenic Microenvironment Reveals Frequency-Dependent Endothelial Response, Y. Sei*, S. Ahn, T. Virtue, T. Kimg, Y. Kim; Georgia Institute of Technology, Atlanta, GA

  • 2:15 p.m. 37. Engineering Cardiac Tissue Mimics as In Vitro Test Beds to Investigate Congenital Heart Disease, D. Bousalis*(1), C. Lacko(1), R. Wachs(2), H. Kasahara(1), C. Schmidt(1); (1)University of Florida, Gainesville, FL, (2)University of Nebraska-Lincoln, Lincoln, NE

  • 2:30 p.m. 38. Biomimetic Microfluidic Networks in Synthetic and Natural Hydrogels for Vessel-on-a-Chip Applications, K. Keller, J. Sperduto, J. Slater*; University of Delaware, Newark, DE

  • 2:45 p.m. 39. Metabolically-Driven Maturation of iPS-Cell Derived Cardiomyocytes in Microphysiological Systems, N Huebsch*, B Charrez, B Siemons, K Onishi, S Boggess, F Montiel, N Deveshwar, N Jeffries, A Stahl, E Miller, K Healy; University of California, Berkeley, CA