Glycomaterials

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Biomaterials for Immunity and Cancer
Room: 210/211

About

Carbohydrates, including monosaccharides, oligosaccharides, polysaccharides, and their conjugates, are major components of all living organisms that play a central role in numerous normal and pathological processes. Thus, carbohydrates are gaining interest as both targets and bioactive components of therapeutics and diagnostics for various biomedical and biotechnological applications. Carbohydrate-containing biomaterials (i.e. "glycomaterials") are receiving particular attention because they provide unique opportunities to mimic the multivalent carbohydrate presentation in native glycoconjugates that is often central to carbohydrate function within living systems. This session will highlight recent advances in the synthesis, characterization, and use of glycomaterials to interrogate and harness the biological activity of carbohydrates for biomedical and biotechnological applications. Particular emphasis will be placed on synthetic glycomaterials to probe glycocalyx function, modulate lectin activity, and engage the immune system for infection prophylaxis and immunotherapy.

Abstracts

  • 10:30 a.m. 351. Invited Speaker: Theresa Reineke, PhD, University of Minnesota

  • 11:00 a.m. 352. Development of a Glycocalyx Mimetic, A Panitch*(1), J Wodicka(2), V Morikis(1), A Chambers(2), G Sangha(2), C Goergen(2), S Simon(1); (1)University of California, Davis, CA, (2)Purdue University, West Lafayette, IN

  • 11:15 a.m. 353. Intra-Articular TSG-6 Delivery from Heparin-based Microparticles Reduces Cartilage Damage in a Rat Model of Osteoarthritis, L. Tellier*, E. TreviƱo, D. Reece, N. Willett, R. Guldberg, J. Temenoff; (1)Georgia Institute of Technology and Emory University, Atlanta, GA, (2)Georgia Institute of Technology, Emory University, and Atlanta Veterans Affairs Center, Atlanta, GA, (3)Georg

  • 11:30 a.m. 354. Hyaluronic Acid Modification Alters CD44 Binding in Soluble and Hydrogel Forms, M. Kwon*(1), C. Wang(2), L. Han(2), R. Mauck(1), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, (2)Drexel University, Philadelphia, PA

  • 11:45 a.m. 355. Viscoelastic Hyaluronic Acid (HA) Hydrogels to Study Hepatic Stellate Cell Mechanobiology, E. Hui*, G. Guan, S. Caliari; University of Virginia, Charlottesville, VA

  • 12:00 noon 356. Glycosylation-dependent hierarchical assembly of low-fouling supramolecular hydrogels, A Restuccia*, G Hudalla; University of Florida, Gainesville, FL

  • 12:15 p.m. 357. Glyco-adjuvant vaccines for enhanced cellular and humoral immunity, D Wilson*, M Raczy, M Swartz, J Hubbell; University of Chicago, Chicago, IL

Invited Speaker(s)