Local Drug, Protein, and Gene Delivery from Implant Surfaces and Coatings

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Drug Delivery
Room: Grand Ballroom B


This general session will focus on the recent advances in locally delivering drugs, proteins, peptides, growth factors, enzymes, and genes from implant surfaces and coatings. Such drug and biomolecule releasing coatings have tremendous applications in cardiovascular devices, orthopedic and fracture fixation devices, craniofacial and dental implants, ophthalmic implants, cochlear implants, and neural devices. This session will cover a wide range of drug and biomolecule eluting implant coatings that include but not limited to novel biodegradable, biostable, and biological polymer coatings, ceramic coatings, porous, textured, microrough, and reservoir surfaces, organic and molecular coatings, selfassembly coatings, solgel coatings, biodegradable metal coatings, thin films, biological and biomimetic coatings. This session will also highlight the importance of different surface characterization techniques to analyze the drug delivery coatings. A special emphasis will be provided to the implant coating technologies that have been translated into clinical and preclinical products.


  • 10:30 a.m. 321. Fluorescent Tagging of Interleukin-4 for Visualizing In-Vivo Release from Coated Polypropylene Mesh, A Nolfi*, D Hachim, A Iftikhar, B Brown; University of Pittsburgh, Pittsburgh, PA

  • 10:45 a.m. 322. In vitro and in vivo mRNA Delivery via poly (2-hydroxyethyl methacrylate) Porous Scaffolds, R. Chen*, H. Zhang, J. Bryers; University of Washington, Seattle, WA

  • 11:00 a.m. 323. Nitric Oxide Releasing Nanomatrix to Enhance Dialysis Fistula Maturation, P Hwang*(1), G Alexander(2), M Somarathna(2), R Milican(1), B Brott(1), J Pollock(2), T Lee(2), H Jun(1); (1)Endomimetics, LLC, Birmingham, AL, (2)University of Alabama at Birmingham, Birmingham, AL

  • 11:15 a.m. 324. Characterization of Carbon Monoxide Releasing Poly(diol-citrate) Polymer for Vascular Applications, D Lichlyter*, A Webb; University of Florida, Gainesville, FL

  • 11:30 a.m. 325. Degradable Devices for Localized Delivery of Immunosuppressants to Prevent Transplant Rejection, J. Molde*(1), K. Dube(1), C. Iovine(1), A. Merolli(1), O. Ortiz(1), J. Steele(1), A. Lellouch(2), Z. Yang Ng(2), I. Schol(2), C. Cetrulo(2), J. Kohn(1); (1)Rutgers University, Piscataway, NJ, (2)Massachusetts General Hospital, Charlestown, MA

  • 11:45 a.m. 326. Controlled Delivery of Local Anesthetics from Novel Biocompatible Wound Dressings, P Alvarez-Urena*, S Bhattacharyya, F Li, P Ducheyne; University of Pennsylvania, Philadelphia, PA

  • 12:00 noon 327. Bioactive Release of Doxycycline from Extracellular Matrix Protein Based Composites, Q. Nguyen*, A. Benton, M. Marquart, A. Janorkar; University of Mississippi Medical Center, Jackson, MS

  • 12:15 p.m. 328. Applying multi-detector GPC/SEC to complex characterization of drug delivery polymers, M. Pothecary*(1), C. Schindler(1), G. Zhang(2), H. Shen(2); (1)Malvern Instruments, Houston, TX, (2)Houston Methodist Research Institute, Housotn, TX