Materials for Cardiovascular Devices and Blood Compatibility

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Biomaterials Applications
Room: 208/209


Thrombosis is often a major concern with cardiovascular medical devices such as stents, vascular grafts, heart valves, pacemakers, defibrillators, ventricular assist devices, cardiopulmonary bypass, and artificial heart. Although significant progress has been made in developing and using a wide variety of metallic, polymeric, ceramic, and natural biomaterials for making cardiovascular medical devices, still the blood compatibility of these devices remains an issue. This symposium will focus on (i) recent developments in cardiovascular biomaterials for improving blood compatibility? (ii) the development of novel biomaterials for cardiovascular medical device applications? (iii) novel coatings and surface modification technologies for improving blood compatibility? (iv) recent developments in in vitro and in vivo evaluation of blood compatibility of biomaterials and medical devices? (v) clinical evaluation of cardiovascular medical devices? (vi) novel approaches to improve endothelialization of cardiovascular implants and devices.


  • 10:15 a.m. 433. Bacteria and Blood Coagulation Responses to Textured/Nitric Oxide Releasing Biomaterial Surfaces, L. Xu*(1), D. Sun(1), T. Wood(2), M. Meyerhoff(3), C. Siedlecki(4); (1)The Pennsylvania State University College of Medicine, Hershey, PA, (2)The Pennsylvania State University, University Park, PA, (3)University of Michigan, Ann Arbor, MI, (4)Penn State u

  • 10:30 a.m. 434. Thrombogenicity Evaluation of Medical Device Materials with an In Vitro Flow Loop System Under Varying Flow Conditions, M. Jamiolkowski, M. Golding, Z. Goddard, R. Malinauskas, Q. Lu*; US Food and Drug Administration, Silver Spring, MD

  • 10:45 a.m. 435. In Vitro Accelerated Fatigue Study of Chimney Stent-grafts Deployed in a Patient's Aortic Aneurysm Phantom, R Zhang*(1), S Crawford(2), I Robertson(3), S Marks(4), M King(1); (1)North Carolina State University, Raleigh, NC, (2)Vascular Surgery, Toronto, ON, (3)NC State Veterinary Hospital, Raleigh, NC, (4)Critical Care and Internal Medicine, Raleigh, NC

  • 11:00 a.m. 436. Design of a shape memory polymer, poly-glycerol dodecanoate, and small intestinal submucosa (Cormatrix┬«) composite material for atrial septal defect occlusion in a porcine model, H Ramaraju*(1), L Solorio(2), M Bocks(3), S Hollister(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)Cook Biotech Inc, West Lafayette, IN, (3)UH Rainbow Babies and Children's Hospital, Cleveland, OH

  • 11:15 a.m. 437. Heparin-functionalized polymer graft surface eluting MK2 inhibitory peptide for vascular graft applications, Y Lee*(1), P Le Thi(2), G Seon(3), C Brophy(4), Y Kim(1), J Park(3), K Park(2), J Cheung-Flynn(4), H Sung(3); (1)Georgia Institute of Technology, Atlanta, GA, (2)Ajou University, Suwon, Republic of Korea, (3)Yonsei University College of Medicine, Seoul, Republic of Korea

  • 11:30 a.m. 438. Surface fluorination of polylactides for enhanced hemocompatibility, R Khalifehzadeh*, B D.Ratner; University of Washington, Seattle, WA

  • 11:45 a.m. 439. Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic Conditions, G. Alexander*(1), P. Hwang(1), J. Chen(1), J. Kim(1), B. Brott(1), Y. Yoon(2), H. Jun(1); (1)University of Alabama at Birmingham, Birmingham, AL, (2)Emory University, Atlanta, GA

  • 12:00 noon 440. In-vitro oxidative stability of high strength siloxane poly(urethane-urea) elastomers developed for heart valve application, L Dandeniyage*(1), P Gunatillake(2), R Adhikari(2), M Bown(2), R Shanks(3), B Adhikari(3); (1)RMIT University / Commonwealth Scientific and Industrial Research Organisation (CSIRO), Melbourne, Australia, (2)Commonwealth Scientific and Industrial Research