Protein and Cells Interfaces

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Wound Healing and Cellular Microenvironment
Room: 208/209


The goal of this broad session is to advance the understanding of cell and protein interactions with natural and synthetic biomaterials. Recent advances related to the mechanistic interactions with existing biomaterials and the design of new materials to produce targeted responses by proteins and cells are encouraged. Topics of interest include, but are not limited to: 1) relating surface chemistry to protein adsorption or specific binding; 2) studying the activation or inactivation of protein function at interfaces, including complement activation; 3) the response of cells to materials with varied chemistries, mechanical properties and micro- or nano-structured surfaces; 4) the evaluation of cell and tissue responses to biomaterials with respect to changes in function or fate; and 5) the role of surface receptors in cell responses, including mammalian and microbial cell types.


  • 1:45 p.m. 386. Contact Activation by The Intrinsic Pathway of Blood Plasma Coagulation, L. Xu, Y. Yan, C. Siedlecki*; The Pennsylvania State University College of Medicine, Hershey, PA

  • 2:00 p.m. 387. A Visual Study of the SynB1-Elastin Like Polypeptide Agglomeration, A. Janorkar, J. Correia, V. Zai-Rose, J. Cobb*; The University of Mississippi Medical Center, Jackson, MS

  • 2:15 p.m. 388. Toll-like Receptor 2-mediated Inflammatory Response to Polymeric Biomaterials, L McKiel, L Fitzpatrick*; Queen's University, Kingston, ON

  • 2:30 p.m. 389. Elucidating Valve Interstitial Cell-ECM Biomechanical Interactions Using Poly(ethylene glycol) Hydrogels, A Khang*(1), A Gonzalez Rodriguez(2), M Schroeder(2), K Anseth(2), M Sacks(1); (1)The University of Texas at Austin, Austin, TX, (2)University of Colorado Boulder, Boulder, CO

  • 2:45 p.m. 390. Covalent tethering of signaling proteins to hydrogels through a reversible thiol-ene bioconjugation, J Grim*(1), B Aguado(1), T Brown(1), K Anseth(2); (1)University of Colorado Boulder, Boulder, CO, (2)University of Colorado Boulder, BioFronteirs Institute, Boulder, CO

  • 3:00 p.m. 391. Engineered Microtopographies to Guide and Control Cellular Response of Fibroblasts and Schwann Cells: SharkletTM Versus Channels, S Mobini*, C Kuliasha, N Bohmann, J Judy, K Otto, C Schmidt, A Brennan; University of Florida, Gainesville, FL

  • 3:15 p.m. 392. Influence of Chitosan-Alginate Scaffold Stiffness on Bone Marrow Stromal Cell Differentiation, I Arias*, M Le, B Ding, K Xu, Z Wang, S Florczyk; University of Central Florida, Orlando, FL

  • 3:30 p.m. 393. Cellular interactions and bone affinity of poly(ethylene sodium phosphate), Y Iwasaki*; Kansai University, Osaka, Japan