Rapid Fire: Engineered Biomaterials for Neural Applications

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Biomaterials Applications
Room: 206/207


Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.


  • Controlled Release

  • 3:15 p.m. 123. Perfusion Stabilizes Long-Term Barrier Function of iPSC-derived Brain Endothelial Cells in 3D Hydrogel Channels, S Faley*, E Hollmann, J Wang, A Bosworth, C Weber, E Lippmann, L Bellan; Vanderbilt University, Nashville, TN

  • 3:20 p.m. 124. Transient blood brain barrier disruption extends therapeutic window for nanoparticle after brain injury, V. Bharadwaj*(1), T. Anderson(2), J. Lifshitz(2), V. Kodibagkar(1), S. Stabenfeldt(1); (1)Arizona State University, Tempe, AZ, (2)University of Arizona, College of Medicine-Phoenix, Phoenix, AZ

  • 3:25 p.m. 125. Electrospun Fibers for Application in Neural Tissue Engineering under Controlled Release, J Xue*, Y Xia; Georgia Institute of Technology, Atlanta, GA

  • 3:30 p.m. 126. Mechanical Properties and PDGF-AA Release Kinetics of a 3D Hydrogel-Microparticle Drug Delivery System Guide Oligodendrocyte Precursor Cell Proliferation and Differentiation, M. Pinezich, L. Russell, N. Murphy, K. Lampe*; University of Virginia, Charlottesville, VA

  • 3:35 p.m. 127. Drug Loaded Polymer Scaffolds for Treatment of Post-Surgical Glioblastoma, E Graham-Gurysh*(1), K Moore(2), E Bachelder(1), C Miller(1), K Ainslie(1); (1)University of North Carolina at Chapel Hill, Chapel Hill, NC, (2)UNC Chapel Hill and North Carolina State University, Chapel Hill, NC

  • Engineered Biomaterials for Neural Applications

  • 3:45 p.m. 128. Subcutaneous maturation of adult NSC-loaded biomaterial scaffolds to spinal cord regionalized neuroepithelium, M Farrag*, N Leipzig; The University of Akron, Akron, OH

  • 3:50 p.m. 129. A Biomaterial for the Prevention of Epidural Fibrosis, S Ing*(1), M Cooke(1), C Tator(2), M Shoichet(1); (1)University of Toronto, Toronto, ON, (2)Toronto Western Hospital, Toronto, ON

  • 3:55 p.m. 130. Sulfated Chondroitin Sulfate Glycosaminoglycan Hydrogel Carriers Improve Transplanted Cell Survival and Enhance Regeneration after Ischemic Stroke in Mice, M. McCrary*(1), K. Jesson(1), G. Sethaputra(1), X. Gu(1), L. Karumbaiah(2), S. Yu(1), L. Wei(1); (1)Emory University, Atlanta, GA, (2)The University of Georgia, Athens, GA

  • 4:00 p.m. 131. Polyvinylpyrrolidone (PVP) dexamethasone controlled release for treatment of neural inflammation after CNS injury, J Johnson*, T Zhao, R Saigal; University of Washington, Seattle, WA

  • 4:05 p.m. 132. Addressing the Effect of DNase Treatment on ECM Preservation and Cell Removal during Sodium Deoxycholate Based Chemical Decellularization of Peripheral Nerve, M. (Mertz) McCrary*, N. Vaughn, Y. Song, C. Schmidt; University of Florida, Gainesville, FL

  • Peripheral Nerves

  • 4:15 p.m. 133. Freeze-cast Core-shell Scaffolds for 10 mm Peripheral Nerve Repair in Rats Sciatic Model, K. Yin*, P. Divakar, J. Hong, K. Moodie, J. Rosen, M. Matthew, U. Wegst; Dartmouth College, Hanover, NH

  • 4:20 p.m. 134. Optimizing Schwann Cell Migration Using Laminin Derived-peptides to Improve Nerve Regeneration, C. Motta*, R. Willits, M. Becker; The University of Akron, Akron, OH

  • 4:25 p.m. 135. Scaling implants from in vivo models to clinical relevance for peripheral nerve repair, K Pawelec*(1), J Koffler(2), A Galvan(1), M Tuszynski(2), J Sakamoto(1); (1)University of Michigan, Ann Arbor, MI, (2)University of California San Diego, La Jolla, CA

  • 4:30 p.m. 136. Preparation and Characterization of Magnetically Templated Hydrogels for Peripheral Nerve Injury Repair, I Singh*, C Lacko, C Schmidt, C Rinaldi; University of Florida, Gainesville, FL

  • 4:35 p.m. 137. Development of an injectable device for peripheral nerve repair, T Prest, C Skillen, C Heisler, K Labelle, R Hartogs, B Brown*; University of Pittsburgh, Pittsburgh, PA