Rapid Fire: Supramolecular Nanomaterials for Drug Delivery, Imaging, and Immunoengineering

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Drug Delivery
Room: Grand Ballroom A

About

Due to the versatility and diversity of their materials properties, a wide range of biomedical applications have emerged in recent years using supramolecular nanomaterials. The bottom-up approach to designing functional objects at the nanoscale has been used to develop individual nanoparticles or to produce highly oriented complexes for a growing number of applications including drug delivery, imaging, theranostics, vaccines, and cancer immunotherapy. In addition, there are exciting opportunities for local therapeutic modulation. This session highlights recent advances in nanomaterials design aimed to enhance the in vivo delivery of therapeutic or imaging payloads for a variety of diseases including those affecting the skin, gastrointestinal and respiratory tracts, cardiovascular system, cancer, and other diseased tissues.

Abstracts

  • 3:15 p.m. 108. Phenylboronic acid-grafted polymer architectures for facile and multifunctional biomolecule delivery into cancer cells, J Kim*(1), W Kim(2); (1)Institute for Basic Science, Pohang, Republic of Korea, (2)POSTECH, Pohang, Republic of Korea

  • 3:20 p.m. 109. Quantitative Supramolecular Drug Loading for Precise Nanomedicine, M. Webber*; University of Notre Dame, Notre Dame, IN

  • 3:25 p.m. 110. Sequential Release of Nanogels from Polymersomes for Dual Intracellular Delivery of Hydrophilic Cargos, F Du*, E Scott; Northwestern University, Evanston, IL

  • 3:30 p.m. 111. Bio-adhesive polymersome for localized and sustained drug delivery at pathological sites with harsh enzymatic and fluidic environment via supramolecular host-guest complexation, M Zhu*, K Wei, S Lin, G Li, L Bian; the Chinese University of Hong Kong, Shatin, Hong Kong

  • 3:35 p.m. 112. Functionalized nanocellulose as stable supports for crystallizing small molecule pharmaceuticals, M Banerjee*, L Willows, B Brettmann; Georgia Institute of Technology, Atlanta, GA

  • 3:45 p.m. 113. CuS-Based Theranostic Micelles for NIR-Controlled Combination Chemotherapy and Photothermal Therapy, and Photoacoustic Imaging, G. Chen(1), B. Ma(1), Y. Wang(1), R. Xie(1), C. Li(2), K. Dou(3), S. Gong*(1); (1)University of Wisconsin-Madison, Madison, WI, (2)The University of Texas MD Anderson Cancer Center, Houston, TX, (3)Fourth Military Medical University, Xi'an, China

  • 3:50 p.m. 114. Surface Engineered Cerium Oxide Nanoparticles Show Promise for Targeting CD44 Expressing Cancer Cells, M Lord, J Whitelock, K Sutradhar*; University of New South Wales, Sydney, Australia

  • 3:55 p.m. 115. Magnetic Nanoparticle Thermal Treatment Potentiates Paclitaxel Activity in Breast Cancer Cells, A Rivera-Rodriguez*, A Chiu-Lam, V Morozov, A Ishov, C Rinaldi; University of Florida, Gainesville, FL

  • 4:00 p.m. 116. Leukocyte-based biomimetic nanoparticles as a targeted drug delivery vehicle for triple-negative breast cancer, M Sushnitha*(1), J Martinez(2), K Hartman(2), M Evangelopoulos(2), E Tasciotti(2); (1)Rice University, Houston, TX, (2)Houston Methodist Research Institute, Houston, TX

  • 4:05 p.m. 117. Supramolecular Nanotherapeutics for Preferential Immune Modulation of the Tumor Microenvironment, A. Kulkarni*(1), S. Natarajan(2), V. Chandrasekar(2), S. Sengupta(2); (1)University of Massachusetts Amherst, Amherst, MA, (2)Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA

  • 4:15 p.m. 118. Multiplexing antibodies in vivo using Z15_EAK, an Fc-binding gelation module, N. Pham*(1), W. Liu(1), E. Gawalt(1), Y. Fan(2), W. Meng(1); (1)Duquesne University, Pittsburgh, PA, (2)Allegheny-Singer Research Institute, Pittsburgh, PA

  • 4:20 p.m. 119. HER2 – Mediated Targeting of an Intracellular Antibody Delivery System to Breast Cancer Cells, A. Dhankher*, C. Lukianov, J. Champion; Georgia Institute of Technology, Atlanta, GA

  • 4:25 p.m. 120. Development of Bone-Targeted Nanocarriers for Delivery of Gli-Inhibitor to the Bone Microenvironment, J. Vanderburgh*, M. Gupta, S. Wang, A. Merkel, J. Sterling, C. Duvall, S. Guelcher; Vanderbilt University, Nashville, TN

  • 4:30 p.m. 121. Guiding Nanomaterials to Tumors for Breast Cancer Precision Medicine: from Tumor-targeting Small Molecule Discovery to Targeted Nano-drug Delivery, P Qiu*, C Mao; University of Oklahoma, Norman, OK

  • 4:35 p.m. 122. Phage enabled ultrasensitive direct detection of circulating microRNA biomarker in human plasma, Y Zeng*, C Mao; University of Oklahoma, Norman, OK