Translation of Nanoparticle Contrast Agents for Clinical X-Ray Imaging Modalities

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Biomaterials Fabrication and Analysis
Room: 204/205


Iodine and barium sulfate have been the only radiographic contrast agents used in clinical medicine for more than 50 years. However, developments in targeted nanoparticle imaging probes over last decade have brought about a renaissance in X-ray contrast media with potential to transform computed tomography into a molecular imaging modality. This session will highlight translational research on nanoparticle imaging probes for radiography, mammography, CT, dual-energy CT, and spectral (multi-energy) CT. Emphasis will be placed on the fundamental biomaterials science underlying the design and synthesis of nanoparticle imaging probes, their performance in imaging phantoms and preclinical models, and prospects for clinical and commercial translation.


  • 4:15 p.m. 261. Invited Speaker: Benjamin Yeh, MD, University of California, San Francisco 4:38 p.m. 262. Invited Speaker: David Cormode, PhD, Hospital of the University of Pennsylvania

  • 5:00 p.m. 263. An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging, J. Hsu*, P. Naha, K. Lau, R. Hastings, P. Chhour, J. Stein, W. Witschey, A. Maidment, D. Cormode; University of Pennsylvania, Philadelphia, PA

  • 5:15 p.m. 264. A Spectral Library of Nanoparticle Contrast Agents for Molecular Imaging with Computed Tomography, T. Curtis*, P. Nallathamby, R. Roeder; University of Notre Dame, Notre Dame, IN

  • 5:30 p.m. 265. Dextran coated cerium oxide nanoparticles (Dex-CeNP): a novel blood pool CT contrast agent, P. Naha*(1), S. Singh(2), D. Cormode(1); (1)University of Pennsylvania, PHILADELPHIA, PA, (2)Ahmedabad University, Ahmedabad, India

  • 5:45 p.m. 266. Synthesis, Characterization and Pre-clinical Evaluation of Iodinated Polymer Nanoparticles as a Contrast Agent for Computed Tomography using a Spectral Photon counting CT, J. Balegamire*(1), Y. Chevalier(1), H. Fessi(1), M. Vandamme(2), E. Chereul(2), S. Si-Mohamed(3), L. Boussel(3), P. Douek(3); (1)University Claude Bernard Lyon 1 - LAGEP, Villeurbanne, France, (2)VOXCAN, Marcy l'Etoile, France, (3)University Claude Bernar

  • 6:00 p.m. 267. In Vivo Detection of Cancer Stem Cells by Dual Mode CT/Fluorescence Using Immunotargeted Nanoparticle Probes, P Nallathamby*(1), K Dahl(2), R Roeder(1); (1)University of Notre Dame, Notre Dame, IN, (2)Indiana University School of Medicine - South Bend, South Bend, IN